Osteoprotegerin (OPG) is a member of the tumour necrosis factor receptor superfamily of proteins. Although initial data illustrated the key role that OPG plays in bone turnover, numerous recent reports indicate that OPG is also an important factor in inflammatory pathways and tumour cell survival. OPG contributes directly to inflammatory processes and has been evaluated as a novel non-invasive biomarker of gut inflammation. Furthermore, OPG affects cell turn-over, differentiation, death and survival via extracellular pathways, correlating with worse prognosis in inflammatory bowel diseases and several gastrointestinal carcinomas. It is now clear that OPG has multiple functions and characteristics. This review gives an overview of OPG, highlights its roles in different extracellular pathways and outlines how OPG could be used as a novel non-invasive biological marker in inflammatory bowel diseases and gastrointestinal carcinomas. This article is protected by copyright. All rights reserved.
Pharmacology, Toxicology and Pharmaceutical Science
3
9%
Biochemistry, Genetics and Molecular Biology
3
9%
Agricultural and Biological Sciences
3
9%
Immunology and Microbiology
3
9%
Other
3
9%
Unknown
11
31%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2016.
All research outputs
#28,746,682
of 34,517,289 outputs
Outputs from Journal of Gastroenterology & Hepatology
#4,044
of 4,654 outputs
Outputs of similar age
#270,047
of 338,048 outputs
Outputs of similar age from Journal of Gastroenterology & Hepatology
#28
of 38 outputs
Altmetric has tracked 34,517,289 research outputs across all sources so far. This one is in the 9th percentile – i.e., 9% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,654 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,048 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
