To compare neonatal acid base status in parturients who underwent cesarean delivery and received either ephedrine or phenylephrine boluses for the treatment of spinal anesthesia induced hypotension.
After institutional review board approval, the perioperative database of the University of Iowa Hospitals and Clinics was used to identify all women diagnosed with preeclampsia and had cesarean delivery under spinal anesthesia for the period January 1 2005 to July 31 2014. Data retrieved included patient demographics, indication for cesarean delivery, severity of preeclampsia, dose of vasopressor, neonatal umbilical artery pH and Apgar scores.
Primary outcome was umbilical artery pH.
Data for 146 patients was included in the analysis. Ephedrine was used in fifty-seven patients (group E) and phenylephrine in eighty-nine (group PE) patients. The median umbilical artery pH was 7.30 (IQR 7.20 - 7.30) and 7.30 (IQR 7.20 - 7.30) in the ephedrine and phenylephrine groups respectively (P=0.41). Non-reassuring fetal heart trace was the only factor significantly associated with lower umbilical artery pH on multivariable regression analysis (β -0.09, P=0.002).
We found no difference in neonatal umbilical artery pH between ephedrine and phenylephrine when used to treat spinal anesthesia induced hypotension during cesarean delivery in preeclamptic patients. Limitations of the study include its retrospective single center design and the fact that the choice of vasopressor was not randomized.
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2018.
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