Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD

Overview of attention for article published in Nature Neuroscience, May 2019

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RT @TweetALSMND: Could motor neuron toxicity in #C9orf72 #ALS be reduced by targeting RAN translation? A new study @NatureNeuro opens up th…

RT @Kazuh_ideA: 認知症(FTD)の原因となるC9orf72遺伝子の繰り返し配列(GGGGCC)の読み取りに必要な因子PAF1、ショウジョウバエを使って同定。毒性タンパク質を産生する“長い”GGGGCCリピートの転写に特異的に作用。FTD脳でPAF1のレベル上昇。…

@TweetALSMND @brookscrickard1 @MolecularCell More recently, relatedly, Paf1 involved in expression of repeats: https://t.co/Yqx55C67jt overall theme is specific requirement of transcription elongation factors in the expression/toxicity of expanded repea…

"Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD" https://t.co/u0DbgESV8a

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