| Title |
Developmental origins of epigenetic transgenerational inheritance
|
|---|---|
| Published in |
Environmental Epigenetics, March 2016
|
| DOI | 10.1093/eep/dvw002 |
| Pubmed ID | |
| Authors | |
| Abstract |
Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic transgenerational inheritance and has been shown in a variety of species including plants, flies, worms, fish, rodents, pigs, and humans. This phenomenon operates during specific critical windows of exposure, linked to the developmental biology of the germ cells (sperm and eggs). Therefore, concepts of the developmental origins of transgenerational inheritance of phenotypic variation and subsequent disease risk need to include epigenetic processes affecting the developmental biology of the germ cell. These developmental impacts on epigenetic transgenerational inheritance, in contrast to multigenerational exposures, are the focus of this Perspective. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| France | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 3 | 2% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 186 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 18% |
| Researcher | 33 | 17% |
| Student > Bachelor | 30 | 16% |
| Student > Master | 18 | 9% |
| Professor | 9 | 5% |
| Other | 24 | 13% |
| Unknown | 42 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 55 | 29% |
| Biochemistry, Genetics and Molecular Biology | 45 | 24% |
| Environmental Science | 10 | 5% |
| Neuroscience | 8 | 4% |
| Medicine and Dentistry | 6 | 3% |
| Other | 24 | 13% |
| Unknown | 43 | 23% |