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CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

Overview of attention for article published in Neurology, February 2012
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Article details
Title
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
Published in
Neurology, February 2012
DOI 10.1212/wnl.0b013e318249f683
Pubmed ID
Authors

J.-M. Lee, E.M. Ramos, J.-H. Lee, T. Gillis, J.S. Mysore, M.R. Hayden, S.C. Warby, P. Morrison, M. Nance, C.A. Ross, R.L. Margolis, F. Squitieri, S. Orobello, S. Di Donato, E. Gomez-Tortosa, C. Ayuso, O. Suchowersky, R.J.A. Trent, E. McCusker, A. Novelletto, M. Frontali, R. Jones, T. Ashizawa, S. Frank, M.H. Saint-Hilaire, S.M. Hersch, H.D. Rosas, D. Lucente, M.B. Harrison, A. Zanko, R.K. Abramson, K. Marder, J. Sequeiros, J.S. Paulsen, G.B. Landwehrmeyer, R.H. Myers, M.E. MacDonald, J.F. Gusella, Alexandra Durr, Adam Rosenblatt, Luigi Frati, Susan Perlman, Patrick M. Conneally, Mary Lou Klimek, Melissa Diggin, Tiffany Hadzi, Ayana Duckett, Anwar Ahmed, Paul Allen, David Ames, Christine Anderson, Karla Anderson, Karen Anderson, Thomasin Andrews, John Ashburner, Eric Axelson, Elizabeth Aylward, Roger A. Barker, Katrin Barth, Stacey Barton, Kathleen Baynes, Alexandra Bea, Erik Beall, Mirza Faisal Beg, Leigh J. Beglinger, Kevin Biglan, Kristine Bjork, Steve Blanchard, Jeremy Bockholt, Sudharshan Reddy Bommu, Bradley Brossman, Maggie Burrows, Vince Calhoun, Noelle Carlozzi, Amy Chesire, Edmond Chiu, Phyllis Chua, R.J. Connell, Carmela Connor, Jody Corey-Bloom, David Craufurd, Stephen Cross, Lucette Cysique, Rachelle Dar Santos, Jennifer Davis, Joji Decolongon, Anna DiPietro, Nicholas Doucette, Nancy Downing, Ann Dudler, Steve Dunn, Daniel Ecker, Eric A. Epping, Diane Erickson, Cheryl Erwin, Ken Evans, Stewart A. Factor, Sarah Farias, Marta Fatas, Jess Fiedorowicz, Ruth Fullam, Sarah Furtado, Monica Bascunana Garde, Carissa Gehl, Michael D. Geschwind, Anita Goh, Jon Gooblar, Anna Goodman, Jane Griffith, Mark Groves, Mark Guttman, Joanne Hamilton, Deborah Harrington, Greg Harris, Robert K. Heaton, Karl Helmer, Machelle Henneberry, Tamara Hershey, Kelly Herwig, Elizabeth Howard, Christine Hunter, Joseph Jankovic, Hans Johnson, Arik Johnson, Kathy Jones, Andrew Juhl, Eun Young Kim, Mycah Kimble, Pamela King, Mary Lou Klimek, Stefan Klöppel, Katherine Koenig, Angela Komiti, Rajeev Kumar, Douglas Langbehn, Blair Leavitt, Anne Leserman, Kelvin Lim, Hillary Lipe, Mark Lowe, Vincent A. Magnotta, William M. Mallonee, Nicole Mans, Jacquie Marietta, Frederick Marshall, Wayne Martin, Sarah Mason, Kirsty Matheson, Wayne Matson, Pietro Mazzoni, William McDowell, Zosia Miedzybrodzka, Michael Miller, James Mills, Dawn Miracle, Kelsey Montross, David Moore, Sasumu Mori, David J. Moser, Carol Moskowitz, Emily Newman, Peg Nopoulos, Marianne Novak, Justin O'Rourke, David Oakes, William Ondo, Michael Orth, Peter Panegyres, Karen Pease, Susan Perlman, Joel Perlmutter, Asa Peterson, Michael Phillips, Ron Pierson, Steve Potkin, Joy Preston, Kimberly Quaid, Dawn Radtke, Daniela Rae, Stephen Rao, Lynn Raymond, Sarah Reading, Rebecca Ready, Christine Reece, Ralf Reilmann, Norm Reynolds, Kylie Richardson, Hugh Rickards, Eunyoe Ro, Robert Robinson, Robert Rodnitzky, Ben Rogers, Adam Rosenblatt, Elisabeth Rosser, Anne Rosser, Kathy Price, Kathy Price, Pat Ryan, David Salmon, Ali Samii, Jamy Schumacher, Jessica Schumacher, Jose Luis Lópenz Sendon, Paula Shear, Alanna Sheinberg, Barnett Shpritz, Karen Siedlecki, Sheila A. Simpson, Adam Singer, Jim Smith, Megan Smith, Glenn Smith, Pete Snyder, Allen Song, Satwinder Sran, Klaas Stephan, Janice Stober, Sigurd Sü?muth, Greg Suter, Sarah Tabrizi, Terry Tempkin, Claudia Testa, Sean Thompson, Teri Thomsen, Kelli Thumma, Arthur Toga, Sonja Trautmann, Geoff Tremont, Jessica Turner, Ergun Uc, Anthony Vaccarino, Eric van Duijn, Marleen Van Walsem, Stacie Vik, Jean Paul Vonsattel, Elizabeth Vuletich, Tom Warner, Paula Wasserman, Thomas Wassink, Elijah Waterman, Kurt Weaver, David Weir, Claire Welsh, Chris Werling-Witkoske, Melissa Wesson, Holly Westervelt, Patrick Weydt, Vicki Wheelock, Kent Williams, Janet Williams, Mary Wodarski, Joanne Wojcieszek, Jessica Wood, Cathy Wood-Siverio, Shuhua Wu, Olga Yastrubetskaya, Justo Garcia de Yebenes, Yong Qiang Zhao, Janice Zimbelman, Roland Zschiegner, Olaf Aaserud, Giovanni Abbruzzese, Thomasin Andrews, Jurgin Andrich, Jakub Antczak, Natalie Arran, Maria J. Saiz Artiga, Anne-Catherine Bachoud-Lévi, Krysztof Banaszkiewicz, Monica Bandettini di Poggio, Oliver Bandmann, Miguel A. Barbera, Roger A. Barker, Francisco Barrero, Katrin Barth, Jordi Bas, Antoine Beister, Anna Rita Bentivoglio, Elisabetta Bertini, Ida Biunno, Kathrine Bjørgo, Inga Bjørnevoll, Stefan Bohlen, Raphael M. Bonelli, Reineke Bos, Colin Bourne, Alyson Bradbury, Peter Brockie, Felicity Brown, Stefania Bruno, Anna Bryl, Andrea Buck, Sabrina Burg, Jean-Marc Burgunder, Peter Burns, Liz Burrows, Nuria Busquets, Monica Busse, Matilde Calopa, Gemma T. Carruesco, Ana Gonzalez Casado, Judit López Catena, Carol Chu, Anna Ciesielska, Jackie Clapton, Carole Clayton, Catherine Clenaghan, Miguel Coelho, Julia Connemann, David Craufurd, Jenny Crooks, Patricia Trigo Cubillo, Esther Cubo, Adrienne Curtis, Giuseppe De Michele, A. De Nicola, Jenny de Souza, A. Marit de Weert, Justo Garcia de Yébenes, M. Dekker, A. Martínez Descals, Luigi Di Maio, Anna Di Pietro, Heather Dipple, Matthias Dose, Eve M. Dumas, Stephen Dunnett, Daniel Ecker, F. Elifani, Lynda Ellison-Rose, Marina D. Elorza, Carolin Eschenbach, Carole Evans, Helen Fairtlough, Madelein Fannemel, Alfonso Fasano, Maria Fenollar, Giovanna Ferrandes, Jaoquim J. Ferreira, Kay Fillingham, Ana Maria Finisterra, K. Fisher, Amy Fletcher, Jillian Foster, Isabella Foustanos, Fernando A. Frech, Robert Fullam, Ruth Fullham, Miguel Gago, RocioGarcía-Ramos García, Socorro S. García, Carolina Garrett, Cinzia Gellera, Paul Gill, Andrea Ginestroni, Charlotte Golding, Anna Goodman, Per Gørvell, Janet Grant, A. Griguoli, Diana Gross, Leonor Guedes, Monica BascuñanaGuerra, Maria Rosalia Guerra, Rosa Guerrero, Dolores B. Guia, Arianna Guidubaldi, Caroline Hallam, Stephanie Hamer, Kathrin Hammer, Olivia J. 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Zaugg, Elzbieta Zdzienicka, Daniel Zielonka, Euginiusz Zielonka, Paola Zinzi, Simone Zittel, Birgrit Zucker, John Adams, Pinky Agarwal, Irina Antonijevic, Christopher Beck, Edmond Chiu, Andrew Churchyard, Amy Colcher, Jody Corey-Bloom, Ray Dorsey, Carolyn Drazinic, Richard Dubinsky, Kevin Duff, Stewart Factor, Tatiana Foroud, Sarah Furtado, Joe Giuliano, Timothy Greenamyre, Don Higgins, Joseph Jankovic, Dana Jennings, Un Jung Kang, Sandra Kostyk, Rajeev Kumar, Blair Leavitt, Mark LeDoux, William Mallonee, Frederick Marshall, Eric Mohlo, John Morgan, David Oakes, Peter Panegyres, Michel Panisset, Susan Perlman, Joel Perlmutter, Kimberly Quaid, Lynn Raymond, Fredy Revilla, Suzanne Robertson, Bradley Robottom, Juan Sanchez-Ramos, Burton Scott, Kathleen Shannon, Ira Shoulson, Carlos Singer, Samer Tabbal, Claudia Testa, Kammen Dan van, Louise Vetter, Francis Walker, John Warner, illiam Weiner, Vicki Wheelock, Olga Yastrubetskaya, Stacey Barton, Janice Broyles, Ronda Clouse, Allison Coleman, Robert Davis, Joji Decolongon, Jeanene DeLaRosa, Lisa Deuel, Susan Dietrich, Hilary Dubinsky, Ken Eaton, Diane Erickson, Mary Jane Fitzpatrick, Steven Frucht, Maureen Gartner, Jody Goldstein, Jane Griffith, Charlyne Hickey, Victoria Hunt, Jeana Jaglin, Mary Lou Klimek, Pat Lindsay, Elan Louis, Clemet Loy, Nancy Lucarelli, Keith Malarick, Amanda Martin, Robert McInnis, Carol Moskowitz, Lisa Muratori, Frederick Nucifora, Christine O'Neill, Alicia Palao, Guerry Peavy, Monica Quesada, Amy Schmidt, Vicki Segro, Elaine Sperin, Greg Suter, Kalo Tanev, Teresa Tempkin, Curtis Thiede, Paula Wasserman, Claire Welsh, Melissa Wesson, Elizabeth Zauber

Abstract

Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG repeat allele has been reported also to influence age at onset, in interaction with the expanded allele. Due to profound implications for disease mechanism and modification, we tested whether the normal allele, interaction between the expanded and normal alleles, or presence of a second expanded allele affects age at onset of HD motor signs.

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X Demographics

X Demographics

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Mendeley demographics

Mendeley demographics

The data shown below were compiled from readership statistics for 510 Mendeley readers of this research output. Click here to see the associated Mendeley record.
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Geographical breakdown

Geographical breakdown
Country Count As %
United States 3 <1%
United Kingdom 2 <1%
Sweden 1 <1%
Portugal 1 <1%
Italy 1 <1%
France 1 <1%
Germany 1 <1%
Czechia 1 <1%
Brazil 1 <1%
Other 1 <1%
Unknown 497 97%

Demographic breakdown

Readers by professional status
Readers by professional status Count As %
Student > Ph. D. Student 82 16%
Student > Bachelor 69 14%
Researcher 66 13%
Student > Master 60 12%
Student > Doctoral Student 27 5%
Other 73 14%
Unknown 133 26%
Readers by discipline
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 86 17%
Agricultural and Biological Sciences 84 16%
Medicine and Dentistry 71 14%
Neuroscience 62 12%
Chemistry 14 3%
Other 52 10%
Unknown 141 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 188. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2025.
All research outputs
#262,857
of 34,089,221 outputs
Outputs from Neurology
#653
of 26,202 outputs
Outputs of similar age
#1,267
of 308,890 outputs
Outputs of similar age from Neurology
#3
of 176 outputs
Altmetric has tracked 34,089,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,202 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,890 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.