BUT, if we are to find therapeutic vulnerabilities to eradicate clones, we need to identify differences between the UBA1 mutant and WT cells. We turned to GoT (https://t.co/erR9NZHN3d), and found expected lymphoid MUT depletion , & unexpected cytoto…
RT @landau_lab: If each one of us has not one genome, but thousands, how to map genotype-phenotype? We need to capture both in a single cel…
If each one of us has not one genome, but thousands, how to map genotype-phenotype? We need to capture both in a single cell. To this end we developed GoT (https://t.co/erR9NZHfdF) and applied it to CHIP in DNMT3A and SF3B1 (https://t.co/UQiSkQQ0ca ; ht…
We first applied GoT (https://t.co/erR9NZHfdF) to MDS with mutated SF3B1, adding CITE-seq for surface proteins. Single-cell mapping showed distinct differentiation biases, protein and mRNA expression differences between mutated and wild type cells with…