Title |
Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France
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Published in |
Infection, Genetics & Evolution, January 2012
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DOI | 10.1016/j.meegid.2012.01.013 |
Pubmed ID | |
Authors |
Marion Vittecoq, Eric Elguero, Kevin D. Lafferty, Benjamin Roche, Jacques Brodeur, Michel Gauthier-Clerc, Dorothée Missé, Frédéric Thomas |
Abstract |
The incidence of adult brain cancer was previously shown to be higher in countries where the parasite Toxoplasma gondii is common, suggesting that this brain protozoan could potentially increase the risk of tumor formation. Using countries as replicates has, however, several potential confounding factors, particularly because detection rates vary with country wealth. Using an independent dataset entirely within France, we further establish the significance of the association between T. gondii and brain cancer and find additional demographic resolution. In adult age classes 55 years and older, regional mortality rates due to brain cancer correlated positively with the local seroprevalence of T. gondii. This effect was particularly strong for men. While this novel evidence of a significant statistical association between T. gondii infection and brain cancer does not demonstrate causation, these results suggest that investigations at the scale of the individual are merited. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 2% |
Vietnam | 1 | 2% |
Saudi Arabia | 1 | 2% |
Unknown | 46 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 18% |
Student > Ph. D. Student | 7 | 14% |
Student > Master | 7 | 14% |
Student > Bachelor | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Other | 10 | 20% |
Unknown | 7 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 37% |
Medicine and Dentistry | 8 | 16% |
Engineering | 3 | 6% |
Environmental Science | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 6 | 12% |
Unknown | 10 | 20% |