Peiyao Jin, Meili Li, Xiangui He, Lina Lu, Jianfeng Zhu, Ta Chen Chang, Haidong Zou

To establish the physiological distribution of anterior-chamber angle parameters and axial length (AL) in a randomly sampled cohort of Chinese children. This was a prospective, cross-sectional study on randomly sampled Chinese children ages 7 to 15 years. Complete ophthalmologic examination was carried out on all participants; anterior-segment parameters and ALs were measured using Fourier-domain optical coherence tomography and automated biometers. Associations between the age, the sex, the refractive error, the iris thickness, the AL, and anterior-chamber depth (ACD) and angle measurements were analyzed using multiple correlation and regression tests. The relationship between the AL and other factors was studied by a linear regression analysis. Only the right eye data were analyzed for statistical purpose. A total of 541 children were enrolled in this study. There were no differences in angle parameters between sexes (P>0.05), but boys had a longer AL (P<0.01). The AL increased logarithmically with age in children (P<0.01, R=0.5552, b=6.18). Although the magnitude of myopia also increased with AL, this association was less robust (P<0.05, R=0.0917, b=-0.88). A multiple regression test indicated that the age and the ACD were independently associated with the increase in angle width (b=0.37 to 0.50 and 0.51 to 0.60, respectively; P<0.001). All angle measurements increased with age and were positively correlated with the ACD in children 7 to 15 years of age. The AL increased logarithmically with age.