IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

Overview of attention for article published in Journal of Clinical Investigation, July 2019

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IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes https://t.co/gzicSlADfi

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes https://t.co/gzicSlj1QI

@AMannanBaig Real difference long-term outcome HCoV hACE2 binding & HCoV hDPP4 binding, 30% SARS/SARS2 experience Long-COVID but 30% MERS patient die. MERS allow insight renal epithelial regeneration take 150-500 day is why take two year LC symptom …

@__ice9 @drbanday There seems to be a pretty good consensus that Type I interferons (alpha and beta) should only be given early, not late in infection. There’s more from the Iowa group than this, but here’s a paper looking at Type I IFN in MERS. https:…

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