Hemodynamic, Hormonal, and Renal Actions of Phosphodiesterase-9 Inhibition in Experimental Heart Failure

Overview of attention for article published in JACC, August 2019

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RT @JACCJournals: Can PDE9-inhibitors benefit natriuretic peptide function and improve hemodynamics in #heartfailure? Find out in this week…

PDEs hydrolyze cAMP & cGMP. PDE9 has the greatest affinity for cGMP, specifically natriuretic peptide-stimulated cGMP. PDE9 inhibitor administered to sheep w pacing induced #CHF had ⬆️cGMP/NP ratio, ⬇️MAP, ⬇️LAP, ⬇️TPR, ⬆️CO, ⬆️Na excretion, ⬆️UOP, ⬆️…

RT @JACCJournals: Can PDE9-inhibitors benefit natriuretic peptide function and improve hemodynamics in #heartfailure? Find out in this week…

RT @JACCJournals: Can PDE9-inhibitors serve as a potential new therapeutic strategy for #heartfailure? Read the latest issue of #JACC to fi…

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