Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region (RBR, envisioned in CTCF-C-terminus away from the narrow Cohesin Retention Domain (CoRD) delineated with confidence https://t.co/NE90K7sI4M near the first N-terminal fing…
RRIDs were included in the Molecular Cell paper "Distinct Classes of Chromatin Loops Revealed by De…" (https://t.co/AaKjei6kUF). We appreciate the author's support of reproducibility. #STMpublishing #ReproducibleResearch
@Hanhui_Ma 2) Also from @AkisPapantonis cell senescence and HMGB2 loss can mediate CTCF clustering: https://t.co/m8TRiwu8DS And CTCF self-association is RNAse sensitive: https://t.co/jxqEYoe4Jn & https://t.co/x4b7QB5V7A So seems like it's complica…
@Hanhui_Ma 1) https://t.co/VQC5q1x1iu --> multiple mechanisms contribute to CTCF clustering: - more cohesin on DNA (via WAPL-AID) ~ more CTCF clustering ~ transcription inhibition ~ more CTCF clustering Prev work: - RBRi-domain in CTCF mediates …