Increasing incidence of inflammatory bowel diseases such as Crohn's disease (CD) in developed nations is associated with changes to the environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota. We find that helminth infection protects mice deficient in the CD susceptibility geneNod2from intestinal abnormalities by inhibiting colonization with an inflammatoryBacteroidesspecies. Colonization resistance toBacteroideswas dependent on type-2 immunity, which promoted the establishment of a protective microbiota enriched in Clostridiales. Additionally, we show that individuals from helminth-endemic regions harbor a similar protective microbiota, and that deworming treatment reduced Clostridiales and increased Bacteroidales. These results support a model of the hygiene hypothesis whereby certain individuals are genetically susceptible to the consequences of a changing microbial environment.
This research output has an Altmetric Attention Score of 670. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2026.
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#40,239
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#1,615
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#581
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#18
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Altmetric has tracked 34,408,222 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 94,074 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.2. This one has done particularly well, scoring higher than 98% of its peers.
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