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Fluoroquinolone-Induced Tendinopathy: Etiology and Preventive Measures

Overview of attention for article published in Tohoku Journal of Experimental Medicine, January 2012
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  • High Attention Score compared to outputs of the same age and source (88th percentile)

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Title
Fluoroquinolone-Induced Tendinopathy: Etiology and Preventive Measures
Published in
Tohoku Journal of Experimental Medicine, January 2012
DOI 10.1620/tjem.226.251
Pubmed ID
Authors

Ferda Kaleagasioglu, Ercan Olcay

Abstract

Tendinopathy is a serious health problem and its etiology is not fully elucidated. Among intrinsic and extrinsic predisposing factors of tendinopathy, the impact of therapeutic agents, especially fluoroquinolone (FQ) group antibiotics, is recently being recognized. FQs are potent bactericidal agents widely used in various infectious diseases, including community acquired pneumonia and bronchitis, chronic osteomyelitis, traveler's diarrhea, typhoid fever, shigellosis, chronic bacterial prostatitis, uncomplicated cervical and urethral gonorrhea and prophylaxis of anthrax. FQs have an acceptable tolerability range. However, many lines of evidence for developing tendinitis and tendon rupture during FQ use have resulted in the addition of a warning in patient information leaflets. FQ-induced tendinopathy presents a challenge for the clinician because healing response is poor due to low metabolic rate in mature tendon tissue and tendinopathy is more likely to develop in patients who are already at high risk, such as elderly, solid organ transplant recipients and concomitant corticosteroid users. FQs become photo-activated under exposure to ultraviolet light, and this process results in formation and accumulation of intracellular reactive oxygen species (ROS). The subsequent FQ-related oxidative stress disturbs mitochondrial functions, leading to apoptosis. ROS overproduction also has direct cytotoxic effects on extracellular matrix components. Understanding the mechanisms of the FQ-associated tendinopathy may enable designing safer therapeutic strategies, hence optimization of clinical response. In this review, we evaluate multi-factorial etiology of the FQ-induced tendinopathy and discuss proposed preventive measures such as antioxidant use and protection from natural sunlight and artificial ultraviolet exposure.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Italy 1 1%
Unknown 79 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 19%
Student > Ph. D. Student 10 12%
Student > Master 7 9%
Student > Doctoral Student 6 7%
Student > Bachelor 5 6%
Other 18 22%
Unknown 20 25%
Readers by discipline Count As %
Medicine and Dentistry 34 42%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Agricultural and Biological Sciences 5 6%
Nursing and Health Professions 4 5%
Chemistry 2 2%
Other 13 16%
Unknown 18 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2017.
All research outputs
#6,636,906
of 25,806,080 outputs
Outputs from Tohoku Journal of Experimental Medicine
#197
of 1,106 outputs
Outputs of similar age
#53,795
of 252,076 outputs
Outputs of similar age from Tohoku Journal of Experimental Medicine
#10
of 86 outputs
Altmetric has tracked 25,806,080 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,076 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.