Title |
Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study
|
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Published in |
Journal of Clinical Biochemistry and Nutrition, February 2010
|
DOI | 10.3164/jcbn.09-100 |
Pubmed ID | |
Authors |
Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans, Najla Guthrie |
Abstract |
Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5-2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic syndrome. Hydrogen rich water was produced, by placing a metallic magnesium stick into drinking water (hydrogen concentration; 0.55-0.65 mM), by the following chemical reaction; Mg + 2H(2)O --> Mg (OH)(2) + H(2). The consumption of hydrogen rich water for 8 weeks resulted in a 39% increase (p<0.05) in antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease (p<0.05) in thiobarbituric acid reactive substances (TBARS) in urine. Further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4. There was no change in fasting glucose levels during the 8 week study. In conclusion, drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome. The portable magnesium stick was a safe, easy and effective method of delivering hydrogen rich water for daily consumption by participants in the study. |
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Japan | 4 | 5% |
United Kingdom | 3 | 3% |
Canada | 3 | 3% |
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Italy | 1 | 1% |
Taiwan | 1 | 1% |
Zimbabwe | 1 | 1% |
Congo, The Democratic Republic of the | 1 | 1% |
Other | 4 | 5% |
Unknown | 39 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 81 | 94% |
Scientists | 3 | 3% |
Practitioners (doctors, other healthcare professionals) | 2 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Chile | 1 | <1% |
United States | 1 | <1% |
Russia | 1 | <1% |
Unknown | 136 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 24 | 17% |
Student > Master | 20 | 14% |
Other | 13 | 9% |
Student > Ph. D. Student | 9 | 6% |
Student > Doctoral Student | 7 | 5% |
Other | 34 | 24% |
Unknown | 33 | 24% |
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---|---|---|
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Agricultural and Biological Sciences | 16 | 11% |
Biochemistry, Genetics and Molecular Biology | 9 | 6% |
Sports and Recreations | 6 | 4% |
Chemistry | 6 | 4% |
Other | 32 | 23% |
Unknown | 39 | 28% |