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Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, November 2001
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

patent
21 patents
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5 Redditors
podcasts
1 podcast

Readers on

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211 Mendeley
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Article details
Title
Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans
Published in
Proceedings of the National Academy of Sciences of the United States of America, November 2001
DOI 10.1073/pnas.201530198
Pubmed ID
Authors
Abstract

Endogenous circadian clocks are robust regulators of physiology and behavior. Synchronization or entrainment of biological clocks to environmental time is adaptive and important for physiological homeostasis and for the proper timing of species-specific behaviors. We studied subjects in the laboratory for up to 55 days each to determine the ability to entrain the human clock to a weak circadian synchronizing stimulus [scheduled activity-rest cycle in very dim (approximately 1.5 lux in the angle of gaze) light-dark cycle] at three approximately 24-h periods: 23.5, 24.0, and 24.6 h. These studies allowed us to test two competing hypotheses as to whether the period of the human circadian pacemaker is near to or much longer than 24 h. We report here that imposition of a sleep-wake schedule with exposure to the equivalent of candle light during wakefulness and darkness during sleep is usually sufficient to maintain circadian entrainment to the 24-h day but not to a 23.5- or 24.6-h day. Our results demonstrate functionally that, in normally entrained sighted adults, the average intrinsic circadian period of the human biological clock is very close to 24 h. Either exposure to very dim light and/or the scheduled sleep-wake cycle itself can entrain this near-24-h intrinsic period of the human circadian pacemaker to the 24-h day.

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Mendeley demographics

Mendeley demographics

The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.
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Geographical breakdown

Geographical breakdown
Country Count As %
United States 2 <1%
Netherlands 2 <1%
Singapore 1 <1%
United Kingdom 1 <1%
France 1 <1%
Spain 1 <1%
Belgium 1 <1%
Australia 1 <1%
Unknown 201 95%

Demographic breakdown

Readers by professional status
Readers by professional status Count As %
Student > Bachelor 30 14%
Student > Ph. D. Student 29 14%
Researcher 29 14%
Student > Master 22 10%
Professor 13 6%
Other 36 17%
Unknown 52 25%
Readers by discipline
Readers by discipline Count As %
Agricultural and Biological Sciences 37 18%
Medicine and Dentistry 26 12%
Psychology 24 11%
Neuroscience 19 9%
Biochemistry, Genetics and Molecular Biology 12 6%
Other 39 18%
Unknown 54 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2026.
All research outputs
#5,029,992
of 34,359,530 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#48,003
of 118,929 outputs
Outputs of similar age
#14,666
of 181,685 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#148
of 487 outputs
Altmetric has tracked 34,359,530 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 118,929 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 487 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.