CD8+ T cells target cerebrovasculature in children with cerebral malaria

Overview of attention for article published in Journal of Clinical Investigation, February 2020

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In the top 5% of all research outputs scored by Altmetric
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news: 8 news outlets
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RT @jclinicalinvest: #clinicalmedicine CD8+ T cells target the brain vasculature in pediatric cerebral malaria https://t.co/m8lYhIupCN @bri…

Dr Riggle begins by describing cerebral malaria: symptoms, pathophysiology, & the P. berghei ANKA model in C57BL/6 mice. You can also find much of this CD8+ study at https://t.co/aWx4CyHe9H

Pretty Striking images in this paper pointing to a role for T cells in human cerebral malaria too. n.b. In P. berghei ANKA, cytotoxicity and (CD4 and) CD8 T cells in vasculature and cuffs required for eCM, in P. chabaudi IL-10 KO, only in vasculature- l…

RT @julia_cutts: So interesting! Many of us malaria researchers have dismissed the mouse model of cerebral malaria because white blood ce…

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