This review converses the Zika virus which has attained global concern due to its rapid pandemic potential and impact on humans. Though Zika virus was first isolated in 1947, till the recent large scale outbreak which occurred in Micronesia, in 2007, the virus was placed into the innocuous pathogen category. It belongs to the genus Flavivirus. The World Health Organization on February 1, 2016, declared it as a "Public Health Emergency of International Concern". Of the note, American as well as Pacific Island strains/isolates are relatively closer to Asian lineage strains. The African and American strains share more than 87.5 and 95% homologies with Asian strains/isolates, respectively. Asian strains form independent clusters, except those isolated from China, suggesting relatively more diversity than African strains. Prevention and control are mainly aimed at the vector population (mosquitoes) with Aedes aegypti being the main species among at least 20 other species. Surveys in Africa and Asia indicated seropositivity in various animal species like Orangutans, Rhesus monkey, Zebra, Elephants, Water buffaloes and rodents. However, so far its natural reservoir is unknown. There is an urgent need to understand why Zika virus has shifted from being a virus that caused mild illness to unforeseen birth defects as well as autoimmune-neurological problems. Unfortunately, an effective vaccine is not available yet. Availability of cryo-electron microscopy based on 3.8 Å resolution revealing mature Zika virus structure and the probable virus attachment site to host cell, would provide critical insights into the development of antiviral treatments and vaccines.