An oxygen-regulated switch in the protein synthesis machinery

Overview of attention for article published in Nature, May 2012

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PubPeer

This paper has 4 comments on PubPeer, an open scientific commentary website.

Peer 1

20 May 2016

Thanks for trying to look into the issue again.Unfortunately there are some issues remaining. I understand compiling the binding sites in CLIP experiments from multiple independent reads - as…

Peer 3

04 May 2016

The major findings of the paper, including the HIF2a/RBM4 interactions, are supported by a wealth of biochemical experiments and reproduced in various settings...

Peer 1

27 Apr 2016

Thanks a lot for trying to look into the issue.I am aware that CLIP libraries from the dawn of these methodologies are generally not comparable in depth with today's libraries...

Peer 3

27 Apr 2016

Thank you for your question. The PAR-CLIP was to provide clues in the search of mRNA that undergo hypoxic translation. To do so, HIF-2a and RBM4 were subjected to the described protocols, bands…

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