RT @SeeFisch: Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes | NEJM https://t.co/KcMgDUeFUq
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10) In #MEDALIST (🔓https://t.co/JMH5XtjY8x), @FenauxP et al showed that #luspatercept ⬇️severity of anemia in pts w/LR-#MDS-RS who had been receiving regular transfusions & were refractory to or unlikely to respond to #ESA. https://t.co/3kutMQlIth
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8c) #Luspatercept is a recombinant fusion protein that binds select transforming growth factor β superfamily ligands to decrease SMAD2 & SMAD3 signaling, thereby enabling erythroid maturation, especially late-stage erythroblast differentiation. See 🔓…
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7. #Luspatercept for transfusion-dependent lower-risk MDS with ring sideroblasts! (8/12) https://t.co/YOG5nYy6km https://t.co/lg6jRzvF4G