@SamueleMarcora The original FIRKO used the less than specific AP2 Cre system and also had signaling through IGF1 receptors. This is a more updated version using of the same experiment from @diabetesmaster https://t.co/9rhhMoTVt4
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@JimJohnsonSci @PaulTitchenell @ethanjweiss @SA_Diabetes Also interesting that FIRKO+FIGFRKO is pretty similar to FIRKO in most ways (other than thermogenesis) https://t.co/jlioV2lejv. Might be that IGF compensation in muscle/BAT more important than in…
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@FatEmperor @StanfordMed You do not need to remind me to be careful of the mouse. I love concordant models which is why I love GH and lipodystrophy... and yes I am well aware of these studies... you know this one? https://t.co/XjkuarQIXw
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@PaulTitchenell @dave_bridges From (most) recent IR/Igf1r DKO paper https://t.co/js3FSYiNxm https://t.co/CzAE41GZ5g