| Title |
Computational methods for predicting genomic islands in microbial genomes
|
|---|---|
| Published in |
Computational and Structural Biotechnology Journal, May 2016
|
| DOI | 10.1016/j.csbj.2016.05.001 |
| Pubmed ID | |
| Authors | |
| Abstract |
Clusters of genes acquired by lateral gene transfer in microbial genomes, are broadly referred to as genomic islands (GIs). GIs often carry genes important for genome evolution and adaptation to niches, such as genes involved in pathogenesis and antibiotic resistance. Therefore, GI prediction has gradually become an important part of microbial genome analysis. Despite inherent difficulties in identifying GIs, many computational methods have been developed and show good performance. In this mini-review, we first summarize the general challenges in predicting GIs. Then we group existing GI detection methods by their input, briefly describe representative methods in each group, and discuss their advantages as well as limitations. Finally, we look into the potential improvements for better GI prediction. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 17% |
| United States | 1 | 17% |
| Netherlands | 1 | 17% |
| France | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 141 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 19% |
| Student > Bachelor | 23 | 16% |
| Researcher | 22 | 15% |
| Student > Master | 21 | 15% |
| Student > Doctoral Student | 13 | 9% |
| Other | 14 | 10% |
| Unknown | 23 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 34% |
| Biochemistry, Genetics and Molecular Biology | 44 | 31% |
| Immunology and Microbiology | 12 | 8% |
| Computer Science | 8 | 6% |
| Medicine and Dentistry | 4 | 3% |
| Other | 1 | <1% |
| Unknown | 26 | 18% |