ASGR1, a liver specific gene, codes for asialoglycoprotein receptor, which is the hepatic receptor for the circulating glycoproteins. (Notice the striking liver specificity of ASGR1 gene expression in GTEx) https://t.co/DcKzHJCyKw https://t.co/r693qkteAl
@EgilFerkingstad Variants associating with levels of a large number of targeted proteins. Of these, the rare LOF at ASGR1 is familiar to the ones following deCODE publications https://t.co/tjlr4iArCw
a) We identified 285 variant-trait pairs with replicated fine-mapping. These include not only known LoF but also e.g a common synonymous rs55714927 on ASGR1 that shows sQTL effect for the same isoform as del12, a rare non-coding deletion reported by deC…
@AAMortazavi @RNAiAnalyst @skathire Variant #ASGR1 Associated with a Reduced Risk of Coronary Artery Disease https://t.co/hzu4O39sb4. $AMGN