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High-Precision Measurement of Variations in Calcium Isotope Ratios in Urine by Multiple Collector Inductively Coupled Plasma Mass Spectrometry

Overview of attention for article published in Analytical Chemistry, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog

Citations

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50 Dimensions

Readers on

mendeley
80 Mendeley
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Title
High-Precision Measurement of Variations in Calcium Isotope Ratios in Urine by Multiple Collector Inductively Coupled Plasma Mass Spectrometry
Published in
Analytical Chemistry, August 2011
DOI 10.1021/ac200361t
Pubmed ID
Authors

Jennifer L. L. Morgan, Gwyneth W. Gordon, Ruth C. Arrua, Joseph L. Skulan, Ariel D. Anbar, Thomas D. Bullen

Abstract

We describe a new chemical separation method to isolate Ca from other matrix elements in biological samples, developed with the long-term goal of making high-precision measurement of natural stable Ca isotope variations a clinically applicable tool to assess bone mineral balance. A new two-column procedure utilizing HBr achieves the purity required to accurately and precisely measure two Ca isotope ratios ((44)Ca/(42)Ca and (44)Ca/(43)Ca) on a Neptune multiple collector inductively coupled plasma mass spectrometer (MC-ICPMS) in urine. Purification requirements for Sr, Ti, and K (Ca/Sr > 10 000; Ca/Ti > 10 000 000; and Ca/K > 10) were determined by addition of these elements to Ca standards of known isotopic composition. Accuracy was determined by (1) comparing Ca isotope results for samples and standards to published data obtained using thermal ionization mass spectrometry (TIMS), (2) adding a Ca standard of known isotopic composition to a urine sample purified of Ca, and (3) analyzing mixtures of urine samples and standards in varying proportions. The accuracy and precision of δ(44/42)Ca measurements of purified samples containing 25 μg of Ca can be determined with typical errors less than ±0.2‰ (2σ).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Poland 1 1%
Germany 1 1%
Unknown 76 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 21%
Student > Ph. D. Student 15 19%
Student > Master 10 13%
Student > Doctoral Student 5 6%
Student > Bachelor 5 6%
Other 12 15%
Unknown 16 20%
Readers by discipline Count As %
Earth and Planetary Sciences 23 29%
Chemistry 11 14%
Biochemistry, Genetics and Molecular Biology 5 6%
Agricultural and Biological Sciences 5 6%
Environmental Science 4 5%
Other 10 13%
Unknown 22 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2012.
All research outputs
#4,120,491
of 22,665,794 outputs
Outputs from Analytical Chemistry
#3,283
of 26,358 outputs
Outputs of similar age
#22,118
of 123,313 outputs
Outputs of similar age from Analytical Chemistry
#25
of 178 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,358 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,313 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 178 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.