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Mendeley readers
Attention Score in Context
| Title |
Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells
|
|---|---|
| Published in |
Cancer Immunology Research, February 2016
|
| DOI | 10.1158/2326-6066.cir-15-0163 |
| Pubmed ID | |
| Authors |
Sandra Van Lint, Dries Renmans, Katrijn Broos, Lode Goethals, Sarah Maenhout, Daphné Benteyn, Cleo Goyvaerts, Stephanie Du Four, Kevin Van der Jeught, Lukasz Bialkowski, Véronique Flamand, Carlo Heirman, Kris Thielemans, Karine Breckpot |
| Abstract |
Modulating the activity of tumor-infiltrating dendritic cells (TiDC) provides opportunities for novel cancer interventions. In this article, we report on our study of the uptake of mRNA by CD8α(+) cross-presenting TiDCs upon its intratumoral (i.t.) delivery. We exploited this property to deliver mRNA encoding the costimulatory molecule CD70, the activation stimuli CD40 ligand, and constitutively active Toll-like receptor 4, referred to as TriMix mRNA. We show that TiDCs are reprogrammed to mature antigen-presenting cells that migrate to tumor-draining lymph nodes (TDLN). TriMix stimulated antitumor T-cell responses to spontaneously engulfed cancer antigens, including a neoepitope. We show in various mouse cancer models that i.t. delivery of TriMix mRNA results in systemic therapeutic antitumor immunity. Finally, we show that the induction of antitumor responses critically depends on TiDCs, whereas it only partially depends on TDLNs. As such, we provide a platform and a mechanistic rationale for the clinical testing of i.t. administration of TriMix mRNA. Cancer Immunol Res; 4(2); 146-56. ©2015 AACR. |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 108 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 29% |
| Researcher | 15 | 14% |
| Student > Doctoral Student | 11 | 10% |
| Student > Bachelor | 8 | 7% |
| Other | 7 | 6% |
| Other | 12 | 11% |
| Unknown | 25 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 21 | 19% |
| Agricultural and Biological Sciences | 15 | 14% |
| Biochemistry, Genetics and Molecular Biology | 13 | 12% |
| Medicine and Dentistry | 10 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 8% |
| Other | 11 | 10% |
| Unknown | 31 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
All research outputs
#1,454,683
of 23,122,481 outputs
Outputs from Cancer Immunology Research
#133
of 1,421 outputs
Outputs of similar age
#27,957
of 398,849 outputs
Outputs of similar age from Cancer Immunology Research
#4
of 49 outputs
Altmetric has tracked 23,122,481 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 398,849 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.