The first example of transition metal-catalyzed meta-selective CAr-H nitration of arenes is described. By using Ru3(CO)12 as the catalyst and Cu(NO3)2.3H2O as the nitro source, a wide spectrum of arenes bearing diversified N-heterocycles or oximido as the directing groups were nitrated with meta-selectivity exclusively and no ortho-nitration was detected. Mechanism studies have demonstrated the formation of a new 18e- octahedral ruthenium species as a key CAr-H metalation intermediate, which may be responsible for the subsequent meta-selective electrophilic aromatic substitution (SEAr). Moreover, this approach provides a fast-track strategy for atom/step economical synthesis of many useful pharmaceutical molecules.
Pharmacology, Toxicology and Pharmaceutical Science
3
2%
Chemical Engineering
1
<1%
Unspecified
1
<1%
Computer Science
1
<1%
Other
5
4%
Unknown
31
24%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2024.
All research outputs
#1,880,500
of 30,202,275 outputs
Outputs from Journal of the American Chemical Society
#2,922
of 76,441 outputs
Outputs of similar age
#23,549
of 317,383 outputs
Outputs of similar age from Journal of the American Chemical Society
#27
of 450 outputs
Altmetric has tracked 30,202,275 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 76,441 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,383 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 450 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.
