ALS/FTD Genes Converge on Endolysosomal System, Stoking TDP-43 Pathology
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18 Oct 2022 Amyotrophic lateral sclerosis and frontotemporal dementia may seem like different diseases, but they are often…
Sans C9ORF72, Microglia Devour More Aβ Plaques … and Synapses, Too
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18 Jun 2021 Hexanucleotide expansions within intron 1 of the C9ORF72 gene not only lead to the production of toxic products…
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.
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Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y…