Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland

https://t.co/eHACiQiA6s "The unanticipated heteromerization between adrenergic and dopamine D4 receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs."

https://t.co/eHACiQiA6s "These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer."

https://t.co/eHACiQiA6s "Through α1B-D4 and β1-D4 receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands." "This inhibition was not observed at hours of the day wh…

https://t.co/eHACiQiA6s "Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D4 receptors."