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Attention Score in Context
| Title |
Antiproliferative activity of ruthenium( ii ) arene complexes with mono- and bidentate pyridine-based ligands
|
|---|---|
| Published in |
Dalton Transactions: An International Journal of Inorganic Chemistry, January 2016
|
| DOI | 10.1039/c6dt01782g |
| Pubmed ID | |
| Authors |
Stefan Richter, Sushma Singh, Dijana Draca, Anup Kate, Anupa Kumbhar, Avinash S. Kumbhar, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Peter Lönnecke, Evamarie Hey-Hawkins |
| Abstract |
A series of Ru(II) arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| Serbia | 1 | 2% |
| Unknown | 40 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 38% |
| Student > Postgraduate | 4 | 10% |
| Student > Master | 4 | 10% |
| Researcher | 3 | 7% |
| Student > Bachelor | 2 | 5% |
| Other | 7 | 17% |
| Unknown | 6 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 27 | 64% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Agricultural and Biological Sciences | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Computer Science | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 6 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2018.
All research outputs
#20,254,701
of 25,756,911 outputs
Outputs from Dalton Transactions: An International Journal of Inorganic Chemistry
#10,214
of 21,221 outputs
Outputs of similar age
#281,147
of 401,844 outputs
Outputs of similar age from Dalton Transactions: An International Journal of Inorganic Chemistry
#658
of 2,102 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 21,221 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 401,844 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,102 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.