Title |
Cucurbitacin E Potently Modulates the Activity of Encephalitogenic Cells
|
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Published in |
Journal of Agricultural & Food Chemistry, June 2016
|
DOI | 10.1021/acs.jafc.6b00951 |
Pubmed ID | |
Authors |
Bojan Jevtić, Neda Djedović, Suzana Stanisavljević, Jovana Despotović, Djordje Miljković, Gordana Timotijević |
Abstract |
Cucurbitacin E (CucE) is a highly oxidized steroid consisting of a tetracyclic triterpene. It is a member of a Cucurbitacin family of biomolecules that are predominantly found in Cucurbitaceae plants. CucE has already been identified as a potent anti-inflammatory compound. Here, its effects on CD4+Thelper (Th) cells and macrophages, as the major encephalitogenic cells in the autoimmunity of the central nervous system were investigated. Production of major pathogenic Th cell cytokines: interferon-gamma and interleukin-17 was inhibited under the influence of CucE. The effects of CucE on CD4+ T cells were mediated through modulation of aryl hydrocarbon receptor, STAT3, NFkappaB, p38 MAPK and miR-146 signaling. Further, production of nitric oxide and reactive oxygen species, as well as phagocytic ability were inhibited in macrophages treated with CucE. These results imply that CucE possess powerful anti-encephalitogenic activity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Serbia | 2 | 12% |
Unknown | 15 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 24% |
Student > Doctoral Student | 3 | 18% |
Librarian | 2 | 12% |
Student > Postgraduate | 2 | 12% |
Student > Ph. D. Student | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 24% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 3 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Neuroscience | 2 | 12% |
Medicine and Dentistry | 2 | 12% |
Other | 2 | 12% |
Unknown | 4 | 24% |