The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

Overview of attention for article published in Nature Communications, June 2020

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日本人痛風患者の8割に関与する尿酸トランスポータABCG2の機能低下型アリルQ141Kについて ABCG2 Q141Kノックインマウスで、Q141Kは腸管では発現が低下し尿酸腸管排泄が消失していることを示した。尿中尿酸排泄が減っていないのに血清尿酸が上がるパラドクス解決PMID: 3248809…

See the latest publication from Otago Biochemistry: The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion. https://t.co/oRbHDDWTiJ Related Articles The ABCG2 Q141K hyperuricemia and gout associated…

RT @G_CANgout: The biological control of urate levels is complex and fascinating. @Goutyprof (Owen Woodward) of the University of Maryland…

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