Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

Overview of attention for article published in Cell Stem Cell, June 2020

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In the top 5% of all research outputs scored by Altmetric
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news: 15 news outlets
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twitter: 44 X users

patent: 27 patents
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So far, Altmetric has seen 15 news stories from 15 outlets.

Chronic HBV infection impairs the glucose metabolism and effector function of NK cells via HBsAg/IL-15/mTOR axis – RawNews

Raw News Health, 14 Oct 2025

Trépo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014;384:2053–63.

CAR immune cells: design principles, resistance and the next generation – Nature

Alert Breaking News - US, 22 Feb 2023

Abramson, J.

iPSC-derived natural killer cells show promise against leukaemia in mice

Drug Target Review, 16 Jun 2020

By deleting the CISH gene from natural killer cells made from iPSCs, researchers say they have effectively treated leukaemia in…

Gene editing turns immune cells into more potent cancer killers

Fierce Biotech, 15 Jun 2020

Natural killer (NK) cells in the immune system are quick to mobilize against foreign invaders, like cancer, but attempts to…

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