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Mendeley readers
Attention Score in Context
| Title |
Biomembranes from slaughterhouse blood erythrocytes as prolonged release systems for dexamethasone sodium phosphate
|
|---|---|
| Published in |
Biotechnology Progress, June 2016
|
| DOI | 10.1002/btpr.2304 |
| Pubmed ID | |
| Authors |
Ivana T Drvenica, Katarina M Bukara, Vesna Lj Ilić, Danijela M Mišić, Borislav Z Vasić, Radoš B Gajić, Verica B Đorđević, Đorđe N Veljović, Aleksandar Belić, Branko M Bugarski |
| Abstract |
The present study investigated preparation of bovine and porcine erythrocyte membranes from slaughterhouse blood as bio-derived materials for delivery of dexamethasone-sodium phosphate (DexP). The obtained biomembranes i.e. ghosts were characterized in vitro in terms of morphological properties, loading parameters, and release behavior. For the last two, an UHPLC/-HESI-MS/MS based analytical procedure for absolute drug identification and quantification was developed. The results revealed that loading of DexP into both type of ghosts was directly proportional to the increase of drug concentration in the incubation medium, while incubation at 37°C had statistically significant effect on loaded amount of DexP (p<0.05). The encapsulation efficiency was about fivefold higher in porcine compared to bovine ghosts. Insight into ghosts' surface morphology by field emission-scanning electron microscopy and atomic force microscopy, confirmed that besides inevitable effects of osmosis, DexP inclusion itself had no observable additional effect on the morphology of the ghosts carriers. DexP release profiles were dependent on erythrocyte ghost type and amount of residual hemoglobin. However, sustained DexP release was achieved and shown over 3 days from porcine ghosts and 5 days from bovine erythrocyte ghosts. This article is protected by copyright. All rights reserved. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 6% |
| Unknown | 15 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 13% |
| Researcher | 2 | 13% |
| Other | 2 | 13% |
| Student > Master | 2 | 13% |
| Unspecified | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 6 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
| Engineering | 2 | 13% |
| Business, Management and Accounting | 1 | 6% |
| Economics, Econometrics and Finance | 1 | 6% |
| Other | 3 | 19% |
| Unknown | 4 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2016.
All research outputs
#4,632,411
of 24,585,562 outputs
Outputs from Biotechnology Progress
#402
of 2,448 outputs
Outputs of similar age
#77,759
of 359,654 outputs
Outputs of similar age from Biotechnology Progress
#10
of 31 outputs
Altmetric has tracked 24,585,562 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,448 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,654 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.