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Seroprevalence of hepatitis E virus in liver transplant patients in Turin, Italy

Overview of attention for article published in Panminerva Medica, July 2020
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Title
Seroprevalence of hepatitis E virus in liver transplant patients in Turin, Italy
Published in
Panminerva Medica, July 2020
DOI 10.23736/s0031-0808.20.03877-x
Pubmed ID
Authors

Elisa Zanotto, Massimo Rittà, Fabrizia Pittaluga, Silvia Martini, Marco Ciotti, Rossana Cavallo, Cristina Costa

Abstract

Acute E hepatitis is usually a self-limited non-progressive disease; however, acute liver failure and death can occur in the presence of particular conditions such as pregnancy and chronic liver diseases. In immunocompromised individuals, such as transplant patients, acute hepatitis E virus (HEV) infection may evolve to chronic hepatitis with rapid progression to liver decompensation. At our center, serology for HEV is not routinely performed in transplant patients and serological status is investigated only on the basis of clinical judgement. In this study, seroprevalence of HEV was evaluated in 217 patients (120 liver transplant recipients and 97 individuals diagnosed with acute or chronic hepatitis). Molecular evaluation of HEV-RNA was also performed. Thirteen patients (6%) showed positivity for HEV-IgG; in particular, 10/120 (8.3%), with concomitant presence of IgM and IgG in six and 3/97 (3.1%). None of the plasma samples tested by HEV-RNA was positive. As the detectable RNA window is narrow and an undetectable HEVRNA result does not exclude recent infection and the transplant context per se represents a risk factor for chronic infection in patients infected with HEV, a routine diagnostic workflow including HEV should be taken into consideration, increasing awareness and knowledge of the basic and clinical aspects of the disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer 1 33%
Other 1 33%
Unknown 1 33%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 33%
Medicine and Dentistry 1 33%
Unknown 1 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2020.
All research outputs
#15,179,141
of 25,387,668 outputs
Outputs from Panminerva Medica
#92
of 265 outputs
Outputs of similar age
#224,971
of 428,853 outputs
Outputs of similar age from Panminerva Medica
#3
of 7 outputs
Altmetric has tracked 25,387,668 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 265 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 428,853 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.