Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

Overview of attention for article published in Cell Reports, July 2020

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@kramer_holly This is a little tangential, but there’s a suggestion that SGLT2i attenuates mTORC1 signaling in PT cells which is thought to be a player in senescence! Caveat is that this is in models of DKD where mTORC1 signaling is high at b/l https://t.…

Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors #Diabetes #Kidney #Disease #immunostaining #imaging #JIRSecondaryAntibodies https://t.co/rtPZB8DtKf

RT @CellReports: Proximal tubule mTORC1 is a central player in the pathophysiology of diabetic nephropathy and its correction by SGLT2 inhi…

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