Toward Small-Molecule Inhibition of Protein–Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions

Overview of attention for article published in Current Topics in Medicinal Chemistry, January 2018

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RT @ProvectusBio: 46/ Molecular Promiscuity: See Bojadzic et al. “Toward Small-Molecule Inhibition of Protein–Protein Interactions: General…

46/ Molecular Promiscuity: See Bojadzic et al. “Toward Small-Molecule Inhibition of Protein–Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions.” See page 9. https://t.co/5…

“...we have identified certain xanthene-based organic dyes, such as erythrosine B and rose bengal, as the first promiscuous SMPPIIs. While their inhibitory mechanism is not entirely clear, it might be related to their rigid flat structures, since planar o…

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