Nature provides answers for efficient transport of water by using Aquaporins AQPs as the translocation relays. Artificial Water Channels biomimicking natural AQPs, can be used for both selective and fast transport of water. Here, we use complementary synthetic methods, X-ray structural data, transport assays to quantify the transport performances of peralkyl-carboxylate-pillar[5]arenes dimers in bilayer membranes. They are able to transport ~107 water molecules/channel/second, within one order of magnitude of AQPs' rates, rejecting Na+ and K+ cations. The dimers have an tubular structure, superposing larger pillar[5]arene pores of 5 Å diameter with narrowest twisted carboxy-phenyl pores of 2.8 Å diameter. This exceptional channel biomimetic platform, with variable pore dimensions within the same structure, offers size restriction reminiscent to natural proteins. It allows water molecules to selectively transit and prevent bigger hydrated cations to pass through the 2.8 Å pore. Molecular simulations probe that dimeric or multimeric honeycomb aggregates are stable in the membrane and form water pathways through the bilayer. Over time, a significant shift of the upper vs. lower layer of occurs initiating new unexpected water permeation events through novel toroidal pores. Altogether, uncovering the interplay between supramolecular construction and transport performances, the novel PAD channels described here are critical to accelerate the systematic discovery for artificial water channels for water desalting.
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2020.
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#9,181,187
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#25,197
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Outputs of similar age from Angewandte Chemie. International Edition
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Altmetric has tracked 34,451,315 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 61,807 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
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We're also able to compare this research output to 902 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
