The formation of complexes between small G proteins and certain of their effectors can be facilitated by aluminum fluorides. Solution studies suggest that magnesium may be able to replace aluminum in such complexes. We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg(2+) and F(-) but without Al(3+). The metallofluoride adopts a trigonal planar arrangement instead of the square planar structure of AlF(4)(-). We have confirmed that these crystals contain magnesium and not aluminum by proton-induced X-ray emission spectroscopy. The structure adopted by GDP.MgF(-) possesses the stereochemistry and approximate charge expected for the transition state. We suggest that MgF3(-) may be the reagent of choice for studying phosphoryl transfer reactions.
Pharmacology, Toxicology and Pharmaceutical Science
2
3%
Computer Science
2
3%
Other
3
4%
Unknown
10
13%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2016.
All research outputs
#22,689,563
of 27,774,969 outputs
Outputs from Chemistry & Biology
#27
of 27 outputs
Outputs of similar age
#53,277
of 55,405 outputs
Outputs of similar age from Chemistry & Biology
#4
of 4 outputs
Altmetric has tracked 27,774,969 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 27 research outputs from this source. They receive a mean Attention Score of 4.3. This one scored the same or higher as 0 of them.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.
