The circadian dynamics of important neuroendocrine-immune mediators have been implicated in progression of rheumatoid arthritis pathophysiology both clinically as well as in animal models. We present a mathematical model that describes the circadian interactions between mediators of the HPA axis and the proinflammatory cytokines. Model predictions demonstrate that chronically elevated cytokine expression results in the development of adrenal insufficiency and circadian variability in paw edema progression. Notably, our model also predicts that an increase in mean secretion of CST after the induction of the disease is accompanied by a decrease in the amplitude of the CST oscillation. Furthermore, alterations in the phase of circadian oscillation of both cytokines and HPA axis mediators are observed. Therefore, by incorporating the circadian interactions between the neuroendocrine-immune mediators our model is able to simulate important features of rheumatoid arthritis pathophysiology.
Pharmacology, Toxicology and Pharmaceutical Science
2
9%
Engineering
2
9%
Biochemistry, Genetics and Molecular Biology
1
4%
Other
1
4%
Unknown
7
30%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2017.
All research outputs
#22,359,103
of 34,763,505 outputs
Outputs from American Journal of Physiology: Endocrinology & Metabolism
#3,511
of 4,862 outputs
Outputs of similar age
#195,379
of 339,866 outputs
Outputs of similar age from American Journal of Physiology: Endocrinology & Metabolism
#31
of 47 outputs
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