@Luke0connor Nice work! Could be interesting to look at late-onset Alzheimer's disease, the only common disease I've ever seen to have evidence of moderate polygenicity (and plausibly under weak selection?): https://t.co/ajebRedbyn
*En general* guiar nuevos tratamientos por los mecanismos que nos descubre el análisis genético ha ido bien (ejemplo más claro en enfermedades cardíacas) y por eso se insiste. Y con Alzheimer ya se sugieren varios mecanismos https://t.co/qkt4jxNKHu https…
one implication of the little line of logic I defended here is that treatments focused on amyloid should work best against early onset monogenic alzheimers. posting this that entirely pwns my hypothesis to show what a big man I am https://t.co/ZRJ8LDIOkK