10/ Auto-Abs were present pre-infection (when samples existed), absent in silent cases, neutralized type I IFN anti–SARS-CoV-2 activity in vitro, and IEI patients in these pathways were prone to critical COVID-19 (https://t.co/pbrg0wysda).
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 https://t.co/OLrWMfq7hi
@sganzerla87 @EdsonFilho74 Zhang et al. (2020): “Inborn errors of type I IFN immunity in patients with life-threatening COVID-19”. Publicado na Science (23 Out 2020). DOI: 10.1126/science.abd4570 Link: https://t.co/BfzTFx6Aa5
Inborn errors of type I IFN immunity in patients with life-threatening #COVID19 https://t.co/WnAw0Z734R
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 | Science https://t.co/YGjmx8pnzg
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 https://t.co/wvbcS1Yecg
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 | Science https://t.co/3Xlg7aOJbK
RT @dr_cottrell: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 https://t.co/Mo1I4kex3v
RT @dr_cottrell: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 https://t.co/Mo1I4kex3v
RT @dr_cottrell: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 https://t.co/Mo1I4kex3v
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 https://t.co/Mo1I4kex3v
RT @chungk1031: Some people have a genetic predisposition to getting sick. Major finding in our understanding of #COVID19 Awesome work i…
@Reezyard @KolsterPeter Sommige mensen overleden aan COVID-19 zonder comorbiditeit omdat ze 'genetisch pech' hadden, zoals een storing in het interferon systeem. https://t.co/qUw1vScJxr
RT @casanova_lab: 5/ These findings replicate and extend our previous observation published in @ScienceMagazine (https://t.co/pbrg0wysda)
RT @casanova_lab: 5/ These findings replicate and extend our previous observation published in @ScienceMagazine (https://t.co/pbrg0wysda)
RT @casanova_lab: 5/ These findings replicate and extend our previous observation published in @ScienceMagazine (https://t.co/pbrg0wysda)
5/ These findings replicate and extend our previous observation published in @ScienceMagazine (https://t.co/pbrg0wysda)
RT @liviozerbini: Scoperto errore genetico che determina nei bimbi la sindrome multisistemica infiammatoria post infezioni virali. Condizio…
RT @casanova_lab: 12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (…
RT @liviozerbini: Scoperto errore genetico che determina nei bimbi la sindrome multisistemica infiammatoria post infezioni virali. Condizio…
RT @casanova_lab: 12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (…
RT @liviozerbini: Scoperto errore genetico che determina nei bimbi la sindrome multisistemica infiammatoria post infezioni virali. Condizio…
RT @liviozerbini: Scoperto errore genetico che determina nei bimbi la sindrome multisistemica infiammatoria post infezioni virali. Condizio…
Co ciekawe, chociaż wrodzone wady lub auto-Abs, które upośledzają aktywność (interferonu) IFN typu I, leżą u podstaw krytycznego zapalenia płuc COVID-19, niedobór tego pojedynczego szlaku indukowanego przez IFN typu I nie leży u podstaw MIS-C. https://t.…
Scoperto errore genetico che determina nei bimbi la sindrome multisistemica infiammatoria post infezioni virali. Condizione grave che può colpire i bimbi post Covid. Importante x poter determinare le persone a rischio di tutte le età in seguito ad infezio…
RT @casanova_lab: 12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (…
RT @casanova_lab: 12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (…
RT @casanova_lab: 12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (…
RT @casanova_lab: 12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (…
RT @casanova_lab: 12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (…
12/ Interestingly, while inborn errors or auto-Abs that impair type I IFN activity underlie critical COVID-19 pneumonia (https://t.co/pbrg0wz02I, https://t.co/oTa8OC8wKp), the deficiency of this single type I IFN-inducible pathway does not – on the contra…
RT @casanova_lab: 2/ Recent achievements of our Dry Lab include the identification of human genetic variants underlying tuberculosis or Cov…
2/ Recent achievements of our Dry Lab include the identification of human genetic variants underlying tuberculosis or Covid-19 (https://t.co/FtOumBHfQ1, https://t.co/ov1yET8IH0, https://t.co/4Xzp1gU2QW).
RT @OlinkProteomics: Casanova: Cytokine storm is a consequence of leukocyte recruitment by Type I IFN. In concl. points to several ref's Ke…
Casanova: Cytokine storm is a consequence of leukocyte recruitment by Type I IFN. In concl. points to several ref's Key 2020 Science https://t.co/zyVnaD2OTp #cytokines2022
RT @Primary_Immune: ⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQ…
RT @Primary_Immune: ⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQ…
RT @Primary_Immune: ⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQ…
RT @Primary_Immune: ⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQ…
RT @Primary_Immune: ⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQ…
RT @Primary_Immune: ⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQ…
RT @Primary_Immune: ⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQ…
⚠️Life-threatening interferon auto-ABs 1⃣ In this 🆕 case -report of a myco-bact infected patient: https://t.co/z4dwWfRQfk #bioinformatics #openscience #scicomm #itrtg 2⃣ And in severe and fatal COVID-19: https://t.co/noDsF19RDg #immunology #raredisease …
RT @0bj3ctivity: @LivRNyyc @NjbBari3 @AbundantLandUse There will be those who are more vulnerable to long COVID, for example due to differe…
@msymeonides @jlamber55605930 @WoollerEmma @organichemusic @loscharlos @LongCovidSOS @long_covid @LongCovidKids @SessionsTlc @patientled @itsbodypolitic @amymitchellart @LongCOVIDPhysio @MECFSNews @research_long There will be many genetic factors confer…
@LivRNyyc @NjbBari3 @AbundantLandUse There will be those who are more vulnerable to long COVID, for example due to differences in genes for type I IFN immunity https://t.co/elg2RSsqfC.
RT @casanova_lab: 2/ The four recessive defects include two previously reported in both adults and children with critical COVID-19 pneumoni…
RT @Primary_Immune: The current paper continues this line of research: "Inborn errors of type I IFN immunity in patients with life-…
RT @Primary_Immune: The current paper continues this line of research: "Inborn errors of type I IFN immunity in patients with life-…
The current paper continues this line of research: "Inborn errors of type I IFN immunity in patients with life-threatening COVID-19" https://t.co/noDsF19RDg #openscience #scicomm
RT @casanova_lab: 2/ The four recessive defects include two previously reported in both adults and children with critical COVID-19 pneumoni…
RT @casanova_lab: 2/ The four recessive defects include two previously reported in both adults and children with critical COVID-19 pneumoni…
RT @casanova_lab: 7/ While plasmacytoid dendritic cells deficient for TLR7 respond poorly to SARS-CoV-2 (https://t.co/IutDfgj8EW), fibrobla…
RT @casanova_lab: 7/ While plasmacytoid dendritic cells deficient for TLR7 respond poorly to SARS-CoV-2 (https://t.co/IutDfgj8EW), fibrobla…
RT @casanova_lab: 7/ While plasmacytoid dendritic cells deficient for TLR7 respond poorly to SARS-CoV-2 (https://t.co/IutDfgj8EW), fibrobla…
RT @casanova_lab: 7/ While plasmacytoid dendritic cells deficient for TLR7 respond poorly to SARS-CoV-2 (https://t.co/IutDfgj8EW), fibrobla…
RT @casanova_lab: 2/ The four recessive defects include two previously reported in both adults and children with critical COVID-19 pneumoni…
7/ While plasmacytoid dendritic cells deficient for TLR7 respond poorly to SARS-CoV-2 (https://t.co/IutDfgj8EW), fibroblast deficient for STAT2 or TYK2 are vulnerable to SARS-CoV-2, as previously shown for IFNAR1-deficient cells (https://t.co/pbrg0wysda…
2/ The four recessive defects include two previously reported in both adults and children with critical COVID-19 pneumonia: AR IFNAR1 and XR TLR7 deficiencies (https://t.co/pbrg0wysda; https://t.co/HJ3CiuwEvk; https://t.co/IutDfgj8EW; https://t.co/BXvov…
@nytimes I hadn’t read this article so maybe others haven’t as well- it’s about the possibility people who are genetically at high risk of severe Covid can be identified https://t.co/dJygr3yqbC
RT @casanova_lab: 3/ Three of the seven patients had been previously reported: a child with critical influenza pneumonia and two 49 and 50…
RT @casanova_lab: The final versions of our two papers were posted and printed yesterday @ScienceMagazine. Paper 1: https://t.co/lDwjvOQRdk…
RT @casanova_lab: 3/ Three of the seven patients had been previously reported: a child with critical influenza pneumonia and two 49 and 50…
3/ Three of the seven patients had been previously reported: a child with critical influenza pneumonia and two 49 and 50 years old adults with critical COVID-19 (https://t.co/RFZWmRpwEH).
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies (PNAS) https://t.co/lxTVETFRgR Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (Science) https://t.co/volBeeyarQ
RT @Primary_Immune: This study should bring new insight into the why of: "Inborn errors of type I IFN immunity in patients with…
This study should bring new insight into the why of: "Inborn errors of type I IFN immunity in patients with life-threatening COVID-19" https://t.co/lryMwMweGF
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
"Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19". https://t.co/DDRV7TiMfA
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 2/ The patient had a history of hospitalizations for severe influenza pneumonia – confirming that influenza and COVID-19…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
RT @casanova_lab: 6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR…
6/ Also surprisingly, the patients are prone to only few viral diseases: influenza, COVID-19, and adverse reaction to MMR, consistent with previous reports (https://t.co/pbrg0wysda; https://t.co/U2S3H3PRRW).
RT @Primary_Immune: Interferons and 🦠COVID-19. Does this ring a bell? https://t.co/qxrjB12fNK https://t.co/pBs4dQR7j8
RT @Primary_Immune: Interferons and 🦠COVID-19. Does this ring a bell? https://t.co/qxrjB12fNK https://t.co/pBs4dQR7j8
Interferons and 🦠COVID-19. Does this ring a bell? https://t.co/qxrjB12fNK https://t.co/pBs4dQR7j8
RT @ImmunoEditor: @MichelsonPhils @ScienceMagazine @ScottBiering @lisa_wagar @MeaganPhelan Paul's essay describes recent work in @ScienceMa…
@MichelsonPhils @ScienceMagazine @ScottBiering @lisa_wagar @MeaganPhelan Paul's essay describes recent work in @ScienceMagazine that helps elucidate the genetics of severe #COVID19! Bastard & al https://t.co/V3Imk7gehq Zhang & al https://t.co…
@KarinHollerthal @leafreedomm Hallo, da bin ich wieder. Gefunden :) Nr.1 https://t.co/dNikDf12i2 https://t.co/b2AKMB1mNZ
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
אז יש המון סיבות, וככלל נהוג לומר שזה 'מולטיפקטוריאלי', כלומר, מושפע גם מאלמנטיים גנטיים, וגם מגורמים סביבתיים. אנחנו יודעים לצורך העניין שאנשים שיש להם דפקט גנטי במנגנוני היצירה של חומרים-אנטי-ויראליים (אינטרפרונים) נוטים לסבול ממחלה קשה מקורונה. https…
Inborn errors of type I IFN immunity in patients with life-threatening #COVID19 https://t.co/1AWHv84xpg "essential roles for both the double-stranded RNA sensor TLR3 and type I IFN cell-intrinsic immunity in the control of #SARSCoV2 infection"
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
@DFisman
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
RT @casanova_lab: 6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.c…
6/ The original data reviewed in this paper can be found in https://t.co/Uxv6KX0Vph, https://t.co/pbrg0wysda, https://t.co/IutDfgj8EW, https://t.co/ep78vsSo3W, https://t.co/brltw4nvLo, https://t.co/j2z8mUTuPC, https://t.co/UkaWGJKd3Z, and https://t.co/S…
RT @Ferhatarslandr: Burada biraz ayrıntısını bulabilirsiniz. https://t.co/dQGGKyxOwy