| Title |
Programmed death ligand 1 expression in hepatocellular carcinoma: Relationship With clinical and pathological features
|
|---|---|
| Published in |
Hepatology, December 2016
|
| DOI | 10.1002/hep.28710 |
| Pubmed ID | |
| Authors |
Julien Calderaro, Benoît Rousseau, Giuliana Amaddeo, Marion Mercey, Cécile Charpy, Charlotte Costentin, Alain Luciani, Elie‐Serge Zafrani, Alexis Laurent, Daniel Azoulay, Fouad Lafdil, Jean‐Michel Pawlotsky |
| Abstract |
The prognosis of hepatocellular carcinoma (HCC) remains poor, with only one third of patients eligible to curative treatments and very limited survival benefits with the use of sorafenib, the current standard-of-care for advanced disease. Recently, agents targeting the PD-L1/PD-1 immune checkpoint were shown to display impressive antitumor activity in various solid or hematological malignancies, including HCC. PD-L1 immunohistochemical expression is thought to represent a biomarker predictive of drug sensitivity. Here, we investigated PD-L1 expression in a series of 217 HCCs and correlated our results with clinical and histological features, and immunohistochemical markers (PD-1, cytokeratin 19, glutamine synthetase, and β-catenin expression). PD-L1 expression by neoplastic cells was significantly associated with common markers of tumor aggressiveness (high serum alpha-foetoprotein (AFP) levels, p=0.038; satellite nodules, p<0.001; macrovascular invasion, p<0.001; microvascular invasion, p<0.001; poor differentiation, p<0.001) and with the progenitor subtype of HCC (cytokeratin 19 expression, p=0.031). High PD-L1 expression by inflammatory cells from the tumor microenvironment also correlated with high serum AFP levels (p<0.001), macrovascular invasion (p=0.001), poor differentiation (p=0.001), high PD-1 expression (p<0.001), and with the so called "lymphoepithelioma-like" histological subtype of HCC (p=0.003). Our study demonstrates that PD-L1 expression by either neoplastic or intratumoral inflammatory cells is related to tumor aggressiveness. It suggests that the response to treatments targeting the PD-L1/PD-1 immune checkpoint could be restricted to particular HCC variants. Thus, enrichment of these tumor subtypes in future clinical trials should be considered. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 133 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 12% |
| Researcher | 16 | 12% |
| Student > Master | 15 | 11% |
| Student > Doctoral Student | 11 | 8% |
| Other | 10 | 7% |
| Other | 30 | 22% |
| Unknown | 38 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 37% |
| Agricultural and Biological Sciences | 12 | 9% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Immunology and Microbiology | 3 | 2% |
| Other | 13 | 10% |
| Unknown | 48 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2021.
All research outputs
#7,960,052
of 25,373,627 outputs
Outputs from Hepatology
#3,823
of 9,093 outputs
Outputs of similar age
#131,554
of 416,449 outputs
Outputs of similar age from Hepatology
#52
of 144 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 9,093 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has gotten more attention than average, scoring higher than 56% of its peers.
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We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.