| Title |
Linoleic acid and the pathogenesis of obesity
|
|---|---|
| Published in |
Prostaglandins & Other Lipid Mediators, June 2016
|
| DOI | 10.1016/j.prostaglandins.2016.06.003 |
| Pubmed ID | |
| Authors | |
| Abstract |
The modern Western diet has been consumed in developed English speaking countries for the last 50 years, and is now gradually being adopted in Eastern and developing countries. These nutrition transitions are typified by an increased intake of high linoleic acid (LA) plant oils, due to their abundance and low price, resulting in an increase in the PUFA n-6:n-3 ratio. This increase in LA above what is estimated to be required is hypothesised to be implicated in the increased rates of obesity and other associated non-communicable diseases which occur following a transition to a modern Westernised diet. LA can be converted to the metabolically active arachidonic acid, which has roles in inducing inflammation and adipogenesis, and endocannabinoid system regulation. This review aims to address the possible implications of excessive LA and its metabolites in the pathogenesis of obesity. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 27% |
| Brazil | 3 | 5% |
| Spain | 3 | 5% |
| United Kingdom | 2 | 3% |
| Canada | 2 | 3% |
| Turkey | 1 | 2% |
| Finland | 1 | 2% |
| New Zealand | 1 | 2% |
| Kenya | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 30 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 54 | 84% |
| Scientists | 6 | 9% |
| Practitioners (doctors, other healthcare professionals) | 4 | 6% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 137 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 21 | 15% |
| Researcher | 20 | 15% |
| Student > Ph. D. Student | 15 | 11% |
| Student > Bachelor | 13 | 9% |
| Other | 8 | 6% |
| Other | 20 | 15% |
| Unknown | 40 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 17% |
| Agricultural and Biological Sciences | 18 | 13% |
| Medicine and Dentistry | 16 | 12% |
| Nursing and Health Professions | 8 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 25 | 18% |
| Unknown | 43 | 31% |