The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum

Overview of attention for article published in Science Signaling, August 2012

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RGS9-2は線条体神経特異的に発現する。本論文ではRGS9-2/Gβ5複合体がAC5の基礎活性・感作・時間的動態を調節すること、RGS9-KOはcAMP産生亢進を示し、オピオイド投与からの離脱時にAC5への感作亢進を示すことを報告した。http://t.co/z7s9RoMY

A protein complex affects drug addiction in mice by influencing production of a second messenger #SciSig http://t.co/uDv7dG9E

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