Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

@EASLnews 30) #Ammonia: The toxin at the centre of pathogenesis & the most misused test in hepatology. It does NOT dx HE, does NOT grade HE, & a ⬆️ level does NOT exclude a subdural. Don't order it to 'confirm' what you already decided. https://t.…

@EASLnews 29) Imaging is for exclusion, not for confirmation: T1 pallidal hyperintensity = manganese, present in most patients with cirrhosis, NOT evidence of HE. EEG slowing/triphasic waves: supportive, non-specific. See https://t.co/ar9Q74K35X https:/…

25) Minimal HE: the iceberg: No symptoms, but falls, car crashes, unemployment, caregiver burden, poor QoL and 2–3X risk of progressing to overt HE. Screen everyone, per https://t.co/UwApggWh4f& https://t.co/ar9Q74Jvgp https://t.co/vazeY12HGP

7) Overt hepatic encephalopathy (#OHE) is a form of HE characterized by clinical symptoms, whereas minimal/covert HE is diagnosed using neuropsychological or neurophysiological tests. See https://t.co/ar9Q74Jvgp.