Zafirlukast is a broad‐spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times

Overview of attention for article published in British Journal of Pharmacology, January 2021

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"the structurally related cysteinyl LT (CysLT ) receptor antagonists zafirlukast and montelukast are powerful inhibitors of thiol isomerase activity." https://t.co/e2NZhLzZ6K

Zafirlukast is a broad‐spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times https://t.co/HmkZIYJ85k

https://t.co/Zaiwke258q "In summary, we provide evidence that the anti‐asthma compound zafirlukast is a potent pan‐thiol isomerase inhibitor which modulates platelet function, cell migration, and thrombosis but does not show detrimental effects on haemos…

https://t.co/Zaiwke258q "Since zafirlukast is able to inhibit at least five enzymes from a family of at least 20 thiol isomerase proteins, such elaborate studies were beyond the scope of this study."

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