SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

#covid19 #diabetes Nov 2020 SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

New from the VMMPC! Coates and colleagues in the Powers Lab. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Mi... https://t.co/pX5JeBggq2

@deepstone13 @naikaik 最近の報告では人間のβ-cellにACE2は発現してないという報告が多いようです。人間のβ-cellにACE2が発現してるかどうかはまだconsensusは取れていないですけどね。コロナで1型糖尿病発症したって聞いたことないですが。https://t.co/7qLvAQjiuA

@JulieRayes Can't access the article, but in the pancreas, ACE2 is probably in pericytes https://t.co/SKiR4LRHjT

RT @Cell_Metabolism: SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but a…

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells. https://t.co/QG9PhNSTrv

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells https://t.co/XTfMMkUEAl

新型コロナウイルスにが膵β細胞に侵入して糖尿病を発症させるのではないかと仮説が立てられたが、どうもそんなことはないらしい。 ウイルス侵入因子であるACE2とTMPRSS2タンパク質の共発現が必要だけど膵β細胞は大丈夫だったよとのこと。 ひとまずは良かった。 https://t.…

RT @hichachu: SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not…

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells https://t.co/2dVsM9TxDV

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

In this study, @powersac_TN and others investigated whether "#SARSCoV2 is directly cytotoxic to pancreatic islet β cells" Read more from @Cell_Metabolism #COVID19 #diabetes https://t.co/0OsmQMi9kf https://t.co/XBrJHTuKII

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells: Cell Metabolism https://t.co/Zj7tPidgcX

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

Another piece of the puzzle. https://t.co/MOxkhzC7xT

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @gorka_orive: Se ha especulado sobre la entrada del SARSCoV2 a células beta pancreáticas y su posible riesgo de inducir diabetes. Un est…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @gorka_orive: Se ha especulado sobre la entrada del SARSCoV2 a células beta pancreáticas y su posible riesgo de inducir diabetes. Un est…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @gorka_orive: Se ha especulado sobre la entrada del SARSCoV2 a células beta pancreáticas y su posible riesgo de inducir diabetes. Un est…

Se ha especulado sobre la entrada del SARSCoV2 a células beta pancreáticas y su posible riesgo de inducir diabetes. Un estudio indica que las células beta no tienen las proteínas de entrada (ACE2 y TMPRSS2) habituales para el virus, lo que reduce el riesg…

RT @DanielJDrucker: Yup-multiple reasons for conflicting #islet #diabetes papers, including validation of reagents/antibodies-cannot rule o…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

#Covid19 new onset diabetes

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @PierFornasari: @EricTopol The same conclusion is presented in another paper on @Cell_Metabolism entitled Expression of SARS-CoV-2 Entry…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

Interesting

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @Cell_Metabolism: SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but a…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @DanielJDrucker: Yup-multiple reasons for conflicting #islet #diabetes papers, including validation of reagents/antibodies-cannot rule o…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @DanielJDrucker: Yup-multiple reasons for conflicting #islet #diabetes papers, including validation of reagents/antibodies-cannot rule o…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

@EricTopol The same conclusion is presented in another paper on @Cell_Metabolism entitled Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 by Irina Kusmartseva et al of Florida University. https…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

Yup-multiple reasons for conflicting #islet #diabetes papers, including validation of reagents/antibodies-cannot rule out a small proportion of ACE2+/TMPRSS2+ beta cells, but VERY rare. The ducts, capillaries and acinar cells more likely ACE2+ #COVID19 …

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

Éric Topol: Quand nous avons vu un nouveau diabète apparaître #T1D se développer chez plusieurs personnes avec #COVID19 , on pensait qu il était du à une attaque via ACE2 exprimée dans les cellules des îlots β pancréatiques. Cela semble maintenant beaucou…

RT @EricTopol: When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 exp…

When we saw new onset diabetes #T1D develop in several people with #COVID19, it was thought to be due to attack via ACE2 expressed in pancreatic β-islet cells. That now appears much less likely. New @Cell_Metabolism by @katie_coate @powersac_TN https://t…

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells https://t.co/P0q6zTOZdF

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells https://t.co/VcuEugo4x8

RT @Cell_Metabolism: SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but a…

RT @DanielJDrucker: The beta cell ACE2 #islet expression dogma debate heats up First data from @powersac_TN @MouseCentral @VanderbiltU http…

RT @Cell_Metabolism: SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but a…

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells: Cell Metabolism https://t.co/eDlpDQvj8K

ACE2 and TMPRSS2 protein is not detected in β cells of the human pancreas https://t.co/BmGt4oplHn

RT @Cell_Metabolism: SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but a…

RT @Cell_Metabolism: SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but a…

The beta cell ACE2 #islet expression dogma debate heats up First data from @powersac_TN @MouseCentral @VanderbiltU

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells https://t.co/4RtNiTaVYu

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Microvasculature and Ducts of Human Pancreas but are Not Enriched in β Cells. https://t.co/TSRkXfTrog