Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose

Overview of attention for article published in British Journal of Clinical Pharmacology, December 2020

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@DrLizaMD @RogerSeheult Dose is relative. Clinical context matters. If sulfation capacity is impaired (gene variants of sulfation-related enzymes, or functional autoAbs against them; other), detoxification may ⬇️ + NAPQI may ⬆️. https://t.co/Vv8XDLIp1b

?8. The addition of inorganic sulphates to formulations of paracetamol, which reduce the relative proportion of hepatotoxic oxidative metabolites. This idea has been floating around for ~30 years @Fiona_M_Russell https://t.co/qlePgsitxJ

https://t.co/TuE6P6KZn1 @JLafGeijerstam @LV_MPA https://t.co/to1P5uY4DC

Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose - Li - 2021 - British Journal of Clinical Pharmacology - Wiley Online Library #SO4 in #Medicine https://t.co/TuE6P6KZn1

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