| Title |
Can dexmedetomidine be a safe and efficacious sedative agent in post-cardiac surgery patients? a meta-analysis
|
|---|---|
| Published in |
Critical Care, September 2012
|
| DOI | 10.1186/cc11646 |
| Pubmed ID | |
| Authors |
Yi Yun Lin, Bin He, Jian Chen, Zhi Nong Wang |
| Abstract |
ABSTRACT: INTRODUCTION: The aim of this study was to explore the use of dexmedetomidine as a safe and efficacious sedative agent in post-cardiac surgery patients. METHODS: A systematic literature search of MEDLINE, EMBASE, the Cochrane Library and Science Citation Index until January 2012 and review of studies was conducted. Eligible studies were of randomized controlled trials or cohort studies, comparing dexmedetomidine with a placebo or an alternative sedative agent in elective cardiac surgery, using dexmedetomidine for postoperative sedation and available in full text. Two reviewers independently performed study selection, quality assessment, and data extraction. RESULTS: The search identified 530 potentially relevant publications; 11 met selection criteria in this meta-analysis. Our results revealed that dexmedetomidine was associated with a shorter length of mechanical ventilation (mean difference -2.70 [-5.05, -0.35]), a lower risk of delirium (risk ratio 0.36 [0.21, 0.64]), ventricular tachycardia (risk ratio 0.27 [0.08, 0.97]) and hyperglycemia (risk ratio 0.78 [0.61, 0.99]), but may increase the risk of bradycardia (risk ratio 2.08 [1.16, 3.74]). But there was no significant difference in ICU stay, hospital stay, and morphine equivalents between the included studies. Dexmedetomidine may not increase the risk of hypotension, atrial fibrillation, postoperative nausea and vomiting, reintubation within 5 days, cardiovascular complications, postoperative infection or hospital mortality. CONCLUSIONS: Dexmedetomidine was associated with shorter length of mechanical ventilation and lower risk of delirium following cardiac surgery. Although the risk of bradycardia was significantly higher compared with traditional sedatives, it may not increase length of hospital stay and hospital mortality. Moreover, dexmedetomidine may decrease the risk of ventricular tachycardia and hyperglycemia. Thus, dexmedetomidine could be a safe and efficacious sedative agent in cardiac surgical patients. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 14% |
| Peru | 1 | 14% |
| Norway | 1 | 14% |
| United Kingdom | 1 | 14% |
| Australia | 1 | 14% |
| United States | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 2% |
| France | 1 | <1% |
| Colombia | 1 | <1% |
| Canada | 1 | <1% |
| Iceland | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 135 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 23 | 16% |
| Researcher | 20 | 14% |
| Student > Master | 20 | 14% |
| Student > Postgraduate | 17 | 12% |
| Student > Doctoral Student | 11 | 8% |
| Other | 34 | 23% |
| Unknown | 20 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 104 | 72% |
| Nursing and Health Professions | 9 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Neuroscience | 2 | 1% |
| Agricultural and Biological Sciences | 2 | 1% |
| Other | 3 | 2% |
| Unknown | 22 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2013.
All research outputs
#5,446,629
of 25,373,627 outputs
Outputs from Critical Care
#3,509
of 6,554 outputs
Outputs of similar age
#39,464
of 190,953 outputs
Outputs of similar age from Critical Care
#34
of 109 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
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We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.