Virus assembly and maturation proceeds through the programmed operation of molecular switches, which trigger both local and global structural rearrangements to produce infectious particles. HIV-1 contains an assembly and maturation switch that spans the C-terminal domain (CTD) of the capsid (CA) region and the first spacer peptide (SP1) of the precursor structural protein, Gag. The crystal structure of the CTD-SP1 Gag fragment is a goblet-shaped hexamer in which the cup comprises the CTD and an ensuing type II β-turn, and the stem comprises a 6-helix bundle. The β-turn is critical for immature virus assembly and the 6-helix bundle regulates proteolysis during maturation. This bipartite character explains why the SP1 spacer is a critical element of HIV-1 Gag but is not a universal property of retroviruses. Our results also indicate that HIV-1 maturation inhibitors prevent unfolding of the CA-SP1 junction and thereby deny access of the viral protease to its substrate.
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2023.
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#16,767,144
of 27,499,142 outputs
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#13,713
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#178,780
of 331,999 outputs
Outputs of similar age from eLife
#226
of 297 outputs
Altmetric has tracked 27,499,142 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,801 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.9. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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