Previous studies have demonstrated that patients with major depression following stroke have a greater degree of cognitive impairment than nondepressed patients with comparable lesions. The present study examined the longitudinal course of cognitive impairment related to depression. Patients were prospectively evaluated following an acute stroke (N = 309), using a structured psychiatric interview and the Mini-Mental State Examination. Longitudinal evaluations were obtained at 3, 6, 12, and 24 months follow-up in a subset of these patients. During the initial in-hospital evaluation, the frequency and severity of cognitive impairment was significantly greater in patients with major depression compared with nondepressed patients. This effect occurred predominantly in patients with major depression following left hemisphere stroke. The association of depression and cognitive function was strongest during the initial evaluation, but was present for up to 1 year. The year-long effect, however, was evident only in patients with left hemisphere stroke. Patients with both depression and cognitive impairment had a greater duration of depression than depressed patients without cognitive impairment. Depression with cognitive impairment appears to be a phenomenon produced by left hemisphere lesions. This suggests that left hemisphere stroke may produce depression through a different mechanism than lesions in other locations. In addition, the fact that the strongest influence of depression on cognitive function was seen during the initial evaluation suggests that this phenomenon may be mediated by acute or subacute physiological effects of the lesion.
Pharmacology, Toxicology and Pharmaceutical Science
2
4%
Social Sciences
2
4%
Business, Management and Accounting
1
2%
Other
2
4%
Unknown
14
30%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2016.
All research outputs
#23,764,151
of 34,151,039 outputs
Outputs from Journal of Nervous & Mental Disease
#2,380
of 3,708 outputs
Outputs of similar age
#28,631
of 30,536 outputs
Outputs of similar age from Journal of Nervous & Mental Disease
#5
of 6 outputs
Altmetric has tracked 34,151,039 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,708 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.
